http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1786548-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J2-22 |
| filingDate | 2005-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4f41ad28c252e325a2f66c414493a5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd35f2c1e810a3d1a20c195df901874d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_142638e77e44938895b82daf80befab2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c94ffbf8896f8ddacff6ffe3a467345 |
| publicationDate | 2007-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1786548-A1 |
| titleOfInvention | GRANULES COMPRISING A ß-LACTAM ANTIBIOTIC |
| abstract | The present invention relates to granules comprising a ß-lactam antibiotic, wherein CH2S(72h) < 50 µl of H2S gas per kg of β-lactam antibiotic, wherein CH2S(72h) is the volume of H2S gas above said granules per kg of said β-lactam antibiotic, when a sample of between 3.5 and 4.5 g of said granules is kept in a closed container having a volume of 20 ml at a temperature of 22 °C during 72 hours at atmospheric pressure (1 bar). The invention also relates to a process for the preparation of granules comprising a ß-lactam antibiotic, said process comprising feeding said β-lactam antibiotic to a roller compactor to form compacts, size reducing, e.g. milling the compacts to produce granules, wherein the temperature of the β-lactam antibiotic that is fed to the roller compactor is sufficiently low that CH2S(72h) < 50 µl of H2S gas per kg of β-lactam antibiotic, wherein CH2S(72h) is the volume of H2S gas above said granules per kg of said β-lactam antibiotic, when a sample of between 3.5 and 4.5 g of said granules is kept in a closed container having a volume of 20 ml at a temperature of 22 °C during 72 hours at atmospheric pressure (1 bar). |
| priorityDate | 2004-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.