| abstract |
A cyclic aminobenzoic acid derivative and an addition salt thereof which are effective as a human peroxisome proliferator-activated receptor (PPAR) agonist, especially an agonist against a human PPARĪ± isoform, in the treatment of lipid metabolism abnormality, diabetes, etc.; and a medicinal composition containing the derivative or salt. The derivative is a cyclic aminobenzoic acid derivative represented by the general formula (1): [Chemical formula 1] [wherein ring Ar represents optionally substituted aryl, etc.; Y represents C1-4 alkylene, C2-4 alkenylene, C2-4 alkynylene, etc.; Z represents oxygen, sulfur, or -(CH2)n- (n is 0, 1, or 2); X represents hydrogen, halogeno, optionally halogenated lower alkyl, etc.; R represents hydrogen or lower alkyl; and -COOR is bonded in an ortho or meta position to the position where the ring W is bonded]. The salt is a pharmacologically acceptable salt of the derivative. |