| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce7bfa46809315703bafbf3a4283168e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8ca73dd169fb8c32d2509ff1723eaff |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2005-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7df3129a95bfb5d2df3bccbb872fc770
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91894089329c7b6bcd31fc9204343737
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f578171b4a883e661b45a912383b193
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3905f7a765b195257e72e18f294512fb |
| publicationDate |
2007-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1773884-A2 |
| titleOfInvention |
Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor |
| abstract |
The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018114578-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018114798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478554-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11433140-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017162663-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643469-B2 |
| priorityDate |
2004-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |