abstract |
The present invention relates to a method of identifying indirect agonists of IGF-1 comprising co-crystallizing a candidate indirect agonist of IGF-1 with IGF-I to form a co-crystalline structure and determining if the candidate agonist binds to one or both of two patches on IGF-1. Furthermore, the invention relates to a co-crystalline complex of IGF-1 and N,N-bis(3-D-gluconamidopropyl)-deoxycholamine. |