http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1765996-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate | 2005-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_437fed2f2bd02e2ae68ce6655ed17d69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17c4c7a73a467bdf36e19096ab34a62f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df3132c965e1bbb281f922f5d3743f35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faaa03831b97e9370f5b2fefd258579d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ffae0be3a044a31935ba5e02485595f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_348f641e7420bb237bd7c7ef74faeff7 |
| publicationDate | 2007-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1765996-A2 |
| titleOfInvention | Mammalian endonucleases and methods of use |
| abstract | Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described. |
| priorityDate | 2004-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1608.