| abstract |
The present invention relates to a composition comprising: i) an HBcAg 1-x , where x is an integer in the range of 100 to 160, a fragment of this antigen, a variant of this antigen or of the fragment of this antigen, or at least two thereof ΓΌ) an adjuvant comprising a saponin or a saponin derivative or a mixture of at least two thereof, and optionally iii) an HBsAg, a fragment of this antigen, a variant of this antigen or the fragment of this antigen or at least two thereof.n n n The invention also relates to a method for producing a composition, the composition obtainable by this method, a pharmaceutical formulation, the use of the composition or the pharmaceutical formulation for the treatment and / or prevention of HBV infections and HBV-mediated diseases, the use of the composition or the pharmaceutical formulation for the preparation of a medicament for the treatment and / or prevention of HBV infections and HHV-mediated diseases and a method for the treatment and / or prevention of HBV infections and HBV-mediated diseases. |