abstract |
The invention relates to substituted imidazopyridazine diones of general formula (I) wherein R1 to R4 have the designation defined in patent claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts of said diones, comprising valuable pharmacological properties, especially an inhibitive effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV). |