http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1761772-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ee32909665d6a0a096975026602287 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b1544f777d0578d2b8cc7bf76f53d1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ff80562f0958a86277656e57b511a85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe133a074d523fe4391337c8781eb750 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57017aefa45a25f8eb2b7addc4fe794a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6783f7e863e9406a42aeb9ecf6153c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9624cde3282307a0229094846caf13f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_840a11a5f64819ebc31b5562807e1064 |
| publicationDate | 2007-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1761772-A1 |
| titleOfInvention | New intravenous drug administration and blood sampling model in the awake rat |
| abstract | There is a continuing need for increased throughput in the examination of new chemical entities (NCEs) in terms of the pharmacokinetic (PK) parameters. The aim was to validate a new study method which allows a higher throughput, the examination of inter-animal variability and a reduction in the numbers of animals needed for routine bioavailability studies of NCEs in awake rats. The design uses a new method for intravenous (iv) administration via the saphenous vein in combination with serial blood sampling via the tail vein. The multiple sampling method was compared with single sampling (decapitation) and the effect on haematocrit (Hct) levels was studied. Direct injection in the saphenous vein was compared to iv administration using an indwelling jugular catheter. Using structural different CE's, it was shown that a combination of direct injection via the saphenous vein and multiple sampling from the tail vein produces comparable plasma concentrations and subsequent PK results to the comparator methods. Furthermore, Hct levels remained within recommended levels using a total blood sampling volume of up to 2.1 ml per day. The new technique increases throughput by reducing the time required for preparative surgery, increases the quality by allowing inter-animal comparison of major PK parameters as concentration time curves can be collected from each animal and reduces the number of animals required. |
| priorityDate | 2004-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.