http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1760154-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-13043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 1996-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e621c8d206c0e02b08149541d05981b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81c38682199de7ca9c5cd547ceba2f59 |
| publicationDate | 2007-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1760154-A2 |
| titleOfInvention | sequences from natural or synthetic retroelements having the function of allowing the insertion of nucleotide sequences in a eukaryotic cell |
| abstract | The retroviral vectors contain cis- acting viral elements to obtain expression, encapsidation, reverse transcription, and integration of the retroviral genome nucleic acid sequence. These elements, however, are not useful in the integrated provirus and can be the cause of many problems. The invention relates to a retroviral vector which eliminates the majority of these viral elements. This vector uses including the Cre-lox recombination system of bacteriophage P1. The 32 nucleotide loxP site is inserted within the U3 sequence of the 3'LTR with the gene to be introduced into the cell. Following the duplication of loxP via the LTR, the LTRs can be recombined by the Cre enzyme. The resulting provirus structure in the host genome corresponds to a single LTR carrying a unique copy of the gene to be introduced into the cell. If the Cre expression unit is inserted between the two LTRs, only single LTR proviral structures are found following infection with the retroviral vector. |
| priorityDate | 1995-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 524.