| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_452edf09f236371e61e3fd22a06ded78 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0237
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0244
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C281-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-04 |
| filingDate |
2005-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80353567fffce0f8660b354d25ec403e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3781111c96cbfba8e3f391af687d71 |
| publicationDate |
2007-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1758899-A1 |
| titleOfInvention |
Asymmetric michael and aldol addition using bifunctional cinchona-alkaloid-based catalysts |
| abstract |
One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with 5 base and a compound that has a suitable leaving group, and 2) converting the ring methoxy group to a hydroxy group. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral ketone, comprising the step of: reacting a prochiral electron-deficient alkene or azo compound or prochiral aldehyde or prochiral 10 ketone with a nucleophile in the presence of a catalyst; thereby producing a chiral, non racemic compound; wherein said catalyst is a derivatized quinine or quinidine. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of reacting racemic chiral alkene with a nucleophile in the presence of a derivatized quinine or quinidine. |
| priorityDate |
2004-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |