| abstract |
The invention describes novel peptide derivatives of the formula I which are biologically active as ligands of the integrin α v β 6 Cyclo (Arg-X 1 -Asp-X 2 -X 3 -X 4 -X 5 -X 6 -R 1 ) I I wherein X 1 Ser, Gly or Thr, X 2 Leu, Ile, Nle, Val or Phe, X 3 Asp, Glu, Lys or Phe, X 4 Gly, Ala or Ser, X 5 Leu, Ile, Nle, Val or Phe, X 6 Arg, Har or Lys, R 1 is absent or one or more ω-aminocarboxylic acid residues (e), wherein the ω-aminocarboxylic acid residue (s) have a length of 500 to 2500 μm, mean, wherein said amino acids may also be derivatized, including the D and L forms of the optically active amino acid residues, and their physiologically acceptable salts and solvates. |