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filingDate 2006-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07e36690232a02d2e4c4bbdd095190c7
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publicationDate 2007-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1750130-A1
titleOfInvention Methods for producing surfaces that resist non-specific protein binding and cell attachment
abstract A method is disclosed herein for treating a polymeric surface to resist non-specific binding of biomolecules and attachment of cells. The method includes the steps of: imparting a charge to the polymeric surface to produce a charged surface; exposing the charged surface to a nitrogen-rich polymer to form a polymerized surface; exposing the polymerized surface to an oxidized polysaccharide to form an aldehyde surface; and exposing the aldehyde surface to a reducing agent. Advantageously, a method is provided which produces surfaces that resist non-specific protein binding and cell attachment and that avoids the use of photochemical reactions or prior art specially designed compounds.
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