abstract |
The invention relates to compounds of formulae nwherein nR 1 and R 2 are independently from each other and signify lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, OCH(CH 3 )OC(O)-lower alkyl or OCH 2 C(O)N(R 3 )(R 4 ), with the proviso that only one of R 1 or R 2 may be hydroxy; nR 3 and R 4 are independently from each other and signify hydrogen, lower alkyl, lower alkenyl or cycloalkyl; or nR 1 and R 2 form together with the carbon atom, to which they are attached the linking group X, wherein nX is O(CH 2 ) n CH=CH(CH 2 ) n O- or -O(CH 2 ) m O-; nn is 1, 2 or 3; and nm is 4-8. nas well as pharmaceutically acceptable salts of said compounds. Compounds of the present invention can be used for the treatment of diseases where Serum Amyloid P Component depletion has a beneficial effect, in particular in the treatment or prevention of all forms of central and systemic amyloidosis. |