| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7aac1d4e56c4873604a6f85e0873571e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-48 |
| filingDate |
2005-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bb43ffdaa65924a154d62a9c286a6fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02e2bf664c7ba09dc0e4b0378fb4247
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a48ad656ee612cdd68784f10581f62e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1055b2268414fae8d7cc78a280189e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bc4253742f5760a1e9de2d8f8c3066f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e440299d82722424514dd2af9d2b9660
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0769f2c102876e4eb65b62c586baf548
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ecd38e2c885c40c6ca285e6468d0458 |
| publicationDate |
2007-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1737497-A2 |
| titleOfInvention |
Nucleic acid aptamers conjugated to high molecular weight steric groups |
| abstract |
The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size. |
| priorityDate |
2004-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |