| abstract |
A medicine which comprises a combination of an acetylcholine esterase inhibitor and a 5-substituted 3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative represented by the following general formula (I). It is useful for the treatment of memory disorders accompanying neuropsychiatric diseases and other cognition disorders. Also provided are: a method of treatment of any of these diseases which comprises using a combination of these drugs; and a use of the medicine. (In the formula (I), Het is oxadiazolyl; R1 is hydrogen, lower alkyl, cyclo(lower alkyl), lower alkenyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, etc.; and R2 is hydrogen, lower alkyl, cyclo(lower alkyl), (un)substituted aryl, etc.) |