| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92119dd1e393035cc396816ade836b9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2106004ef4eea9314b8f5e0f25264691
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_658c0312745cfa1f28744348ad9015ef |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-724
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate |
2005-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a1d7912e1f819bbe3fd9def2e24995c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b9be0a6e54c88a0288eaab28d23b37e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec44170e36a5d799a6554377f51110f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78e847fc55bd1629fcd589c68fe7aca4 |
| publicationDate |
2006-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1735326-A2 |
| titleOfInvention |
Beta-cyclodextrin derivatives and their use against anthrax lethal toxin |
| abstract |
The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides method for protection against anthrax toxicity. |
| priorityDate |
2004-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |