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filingDate 2005-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af73091e27d7e246b0448983c85b26ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_153a092c30e506ec858995652303ee10
publicationDate 2012-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1735027-B1
titleOfInvention Stabilized biodegradable neurotoxin implants
abstract Biodegradable neurotoxin implants and methods of malting and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time.
priorityDate 2004-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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