| abstract |
The present invention relates to dendrimers being multivalently substituted with active groups, as well as to processes for the preparation thereof and to the use of such multivalent dendrimers. nThe active compounds encompass peptides, including oligopeptides up to entire proteins, carbohydrates and pharmaceutically active drug molecules. nActive compounds are chemoselectively bound to the dendrimer periphery using a cycloaddition reaction (also termed as "click" reaction) between an alkyne group and either an azide or a nitrile oxide, leading to a 1,4-disubstituted 1,2,3-triazole or a 1,4-disubstituted 1,2-oxazole bridging unit. Such reaction is catalyzed by Cu(I) compounds. Microwave irradiation improves the efficiency of the click reaction. |