| abstract |
A biosensor comprises a surface onto which bio-macromolecules are bound, the surface and bio-macromolecules being immersed in liquid, a bond rupture detector associated with the surface and arranged to detect the rupture of bonds between the bio- macromolecules and a target substance (6), and an oscillator (8) associated with the liquid and spaced from the surface and arranged to produce oscillations in the liquid to cause bonds between the bio-macromolecules and the target substance (6) to rupture. |