| abstract |
The invention relates to isopeptides capable of modulating intracellular gap junctional communication. The invention further relates to methods of using the isopeptides to maintain or enhance such communication. In one aspect, the isopeptides are antiarrhythmic isopeptides which target the same cells targeted by AAP, AAP10, HP5, and/or functional analogs thereof, i.e. the isopeptides are able to modulate the function of these cells by agonizing or antagonizing the function of AAP, AAP10, HP5, and/or functional analogs thereof. |