| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c12c65740e940d5e6984f17ac20c5c83 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-782
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-51 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-9789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-9722 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-18 |
| filingDate |
2004-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1d6f436c8e6d07f10b37370ade51a50 |
| publicationDate |
2007-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1699423-B1 |
| titleOfInvention |
Use of a lyophilisate of dedifferentiated plant cells for skin depigmentation and/or lightening |
| abstract |
Use, in a cosmetic or pharmaceutical composition (A), of at least one lyophilizate (B) of dedifferentiated plant cells, where (B) causes depigmentation and/or lightening, protection and regeneration of the epidermis. An independent claim is also included for topical cosmetic or pharmaceutical compositions that contain (B). ACTIVITY : Dermatological. Human keratinocytes and melanocytes were seeded on to polycarbonate filters and grown for 10 days at an air/medium interface to produce a type VI (negroid) epidermis. Samples of this were incubated for an unspecified time with a cream (PXTS; designed for very dry skin) that contained 0.5 % of a lyophilizate of dedifferentiated cells of Crithmum maritimum. Intracellular melanin synthesis was then analyzed spectrometrically at 475 nm; absorbance was 0.160 in a negative control but 0.101 (37 % reduction) in the test sample. A further test showed a 32 % reduction in tyrosinase activity. MECHANISM OF ACTION : Blocking activity of tyrosinase (depigmentation and lightening); scavenging free radicals (protective effect) and/or stimulating proliferation of cells in the basal layer and inhibiting epidermal differentiation (regenerative effect). |
| priorityDate |
2003-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |