| abstract |
Compounds for use in pharmaceutical compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the farnesoid X receptor, and/or orphan nuclear receptors, are provided.: formula (I) or a pharmaceutically acceptable derivative thereof; wherein: R1 is -C(J)OR14, -C(J)SR14 and -C(J)N(R15)R16, J is O, S or NR17, R2 is hydrogen, halo or optionally substituted alkyl; R3 is -C(O)R9, R4, R5, R6 and R7 and R8 are as described in the claims. |