| abstract |
A process for preparing an emulsion composition comprising an ascomycin or a derivative thereof as active agent, which process comprises the step of admixing to a placebo fat emulsion a concentrate comprisingn a) the active agent, b) a stabiliser selected from a phospholipid, a glycolipid, a sphingolipid, a diacylphosphatidyl glycerol, an egg-phosphatidylglycerol, a soy-phosphatidylglycerol, or a salt thereof; or a saturated, mono- or di-unsaturated (C 12-24 ) fatty acid, or a salt thereof, and c) an organic solvent, nwherein the weight ratio of acitve agent to stabiliser is between 400:1 and 0.5:1.n The invention also provides ready-to-use emulsions, e.g. for intravenous administration, prepared using the above process. |