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filingDate 2004-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_774887276bdcf1d4ebaa8d04063d3894
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publicationDate 2006-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1673327-A1
titleOfInvention Process for the preparation of alkynols
abstract Process for the preparation of an alkynol with formula HC≡C-CH(OH)-R<SUP>2</SUP>(formula 2) wherein R<SUP>2 </SUP>represents methyl, halomethyl or ethyl, wherein the corresponding silyl-protected alkynol ester with formula 1 wherein R<SUP>1 </SUP>represents H, or an optionally substituted alkyl, an optionally substituted alkenyl or an optionally substituted (hetero)aryl group, R<SUP>2 </SUP>is as defined above and A<SUB>3</SUB>Si represents a trisubstituted silyl group wherein each A independently represents an optionally substituted alkyl or an optionally substituted (hetero)aryl group, in the presence of water and at least an equivalent amount of amine functionalities is converted into the alkynol with formula 2. Preferably, the amount of water is between 0.5 and 3 equivalents calculated with respect to the amount of silyl-protected alkynol ester with formula (1).
priorityDate 2003-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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