| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C30B7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-205 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C30B7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_024930959958f46ea17cba89469308ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87bae8ae02149b77d416e5e76b8e42f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3389d1a8ecb5d4ffe0716ef784daa2b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64c357463f13e0acd3bddac91359fce0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f1f90053ea4a07173616bf851b40b15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15f2d575312000e1794e22fb5b7d474d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd8b6dc0cbc769255dd40075e506491 |
| publicationDate |
2006-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1669370-A1 |
| titleOfInvention |
Identification of regions of apical membrane antigen 1 of apicomplexan parasites suitable for targeting by vaccines and drugs by derivation and analysis of the three-dimensional structure |
| abstract |
The present invention relates to a crystal of the ectoplasmic domain of Apical Membrane Protein 1 (AMA1) from Plasmodium and a method of crystallisation of such a protein. The invention is also directed to the crystal structure of this AMA1 domain and to the three-dimensional structure of the domain itself, particularly of AMA1 ectodomain from Plasmodium vivax and Plasmodium falciparum . The present invention also provides methods for identifying ligands of this AMA1 ectodomain using the said crystal structure, and to design pharmaceutical compounds capable of interacting or binding to that domain, particularly to certain amino-acid residues of domain I and II identified as contributing to a relevant epitope of that domain, or for identifying vaccine or drug candidates that could be used to inhibit erythocytes invasion by, and/or growth inhibition of, Plasmodial parasites and that can used in pharmaceutical compositions for the prevention or treatment of malaria. The present invention also concerns peptidic fragments on that AMA1 ectodomain, their coding nucleic acid and their uses for the preparation of immunogens or vaccines for the treatment or the prevention of Plasmodial infection. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101595127-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741305-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008074356-A1 |
| priorityDate |
2004-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |