| abstract |
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Formula (I) including salts, solvates, and pharmacologically functional derivatives thereof wherein R1 is OH; each of R2 and R4 independently are selected from OH, alkyl, or halogen; each of p and q independently are selected from 0, 1, or 2; R3 is -(Y)z-R6; z is 0 or 1; Y is -C=C- or CR6=CR1-; X is -(CH2)n- where n is 0, 1, 2, or 3, -C(R9)2-, -O-,or -S-. |