| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51d028c578ae85cb937b5b34a5129fbc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-632
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2521-319 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2003-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_895a5a9b432cd11ea72dd3d82cfd3efa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b893b188e4c24ff5bf4416abbae3d24d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_140178235e01a6d6c859c762dd83fd06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fa1d7d6141be1783b60a3c1d020a099
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa30c80eab4d381875ef6fde2e706b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c81eb880b4de8f71b7d89579aaedb97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca748b765b6b40d4dc56f533529485be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30d783ab28b1112dfc90a26cebd7bbd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3b1f3fdd759495c92c6749b32309dfb |
| publicationDate |
2006-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1664335-A1 |
| titleOfInvention |
Methods to increase nucleotide signals by raman scattering |
| abstract |
The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE48993-E |
| priorityDate |
2003-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |