http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1664305-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c834eb81d6424e6d4f4cefe9cd06e34d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-61 |
| filingDate | 2004-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298eea94b0828a642a58acaac988324a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8acfba52224ab8f4588bbe052bc322a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc778fdce1e3b72bdb66769bf6764873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f67cc182530d5e1d3a0b012b03a84b22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30ad25f371a7fa7c1adbed57c6566771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a8ffd26dda2a6703ff4b4bb6433cdc9 |
| publicationDate | 2006-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1664305-A1 |
| titleOfInvention | Selection system containing non-antibiotic resistance selection marker |
| abstract | A selection system free of antibiotic resistance genes, which is based on the use of an araD gene as a selection marker carried on a vector which is inserted in a bacterial strain deficient of the araD gene. The araD gene from E. coli encodes the L-ribulose-5-phosphate-4-epimerase. A method of selecting the cells transformed with a plasmid, which contains the araD gene. The non-antibiotic selection marker makes the system suitable for producing therapeutics. The araD gene is not essential for growth of the host but manipulation of it affects the growth under certain selective conditions. Deletion of araD leads to accumulation of substance which is toxic to the host but not to humans. The araD gene is relatively small and therefore a small plasmid may be constructed, which requires less energy for replication, and leads to increased growth rate and yield. |
| priorityDate | 2003-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 398.