| abstract |
The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cylce molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle paramteres (molecules) such as CDKI kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin Bl, Cyclin E expression, p2l expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane. |