abstract |
The invention relates to quinazoline derivatives of formula (I)n nin which R 1 , X and A have the meanings as indicated, or to a pharmaceutically acceptable salt thereof, e.g.n n Such compounds are useful as modulators, in particular inhibitors, of the mitotic kinesin Eg5. i.e. the human protein (also called KSP), the Xenopus laevis homologue, further homologues from other species as well as allelic variants and functionally related proteins. n The invention also relates to processes for their preparation, pharmaceutical compositions comprising said quinazoline derivatives, and the use of said quinazoline derivatives, in particular for treating diseases such as cancer. |