http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1645565-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b8c40ecc6ed367224646bc1a9a97dd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96fe5e1d2627cd9758e31c74c2a1e98d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ec2ff8745649d354c3d398c3aeee7bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eefa48f9b21fc8e5b5ceb014f4581255 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-645 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 |
| filingDate | 1998-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_402ec09e525642a661d9376b2c760bd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30393544a294556d26de88ce3cf90432 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffa64e7237d3dff18788faca08d3f8aa |
| publicationDate | 2006-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1645565-A1 |
| titleOfInvention | Deuterated cyclosporine analogs and their use as immunomodulating agents |
| abstract | Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine A (CsA) molecule by: (1) chemical substitution and optionally deuterium substitution of amino acid, 1 and (2) deuterium substitution at key sites of metabolism of the cyclosporine A molecule such as amino acids 1, 4, 9. The most active derivatives of the invention were those possessing both chemical and deuterium substitution. Also disclosed are methods of producing the cyclosporine derivatives and method of producing immunosuppression with reduced toxicity with the disclosed cyclosporine derivatives. |
| priorityDate | 1997-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 336.