| abstract |
The invention relates to a targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted. Said derivatives are Cdc25 phosphatase inhibitors and may be used for the production of medicaments for the treatment of cancer. Also disclosed are synthetic intermediates used in the above production. The invention particularly relates to the following benzothiazole-4,7-dione derivatives: 2-(2-chloro-6-fluorophenyl)-5-{[2-(dimethylamino)ethyl]amino }-1,3-benzothiazole-4,7-dione and 2-(2-chloro-6-fluorophenyl)-5-[(2-pyrrolidin-1-ylethyl)amino]-1,3-benzothiazole-4,7-dione. |