Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32305ca3a8c0b7e8cff4bd2dcd2baf65 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
filingDate |
2004-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123ec28a0a5d168da600659003765634 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4c297379a9c72a4cc6997b781fcec0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8c3772b72aecad360c90f4b3421ad0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd910f4aafdb17dda7b7f6aef0c956f5 |
publicationDate |
2006-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1640454-A1 |
titleOfInvention |
Cd9/cd81 double-null nonhuman animal |
abstract |
An object of the invention is to provide a non-human animal which can be utilized as a model animal well exhibiting a pathological condition of low-turnover type of osteoporosis and chronic obstructive pulmonary disease, for screening therapeutic agents for osteoporosis or therapeutic agents for chronic obstructive pulmonary disease, etc. The invention includes a non-human animal, wherein a gene coding for CD9 and a gene coding for CD81 are deficient at least in somatic cells; and a method to use the non-human animal as an osteoporosis model animal, including a step of measuring the degree of inhibition in the osteogenesis, and a method to use the non-human animal as a chronic obstructive pulmonary disease model animal, including a step of measuring the degree of a phenotype similar to chronic obstructive pulmonary disease. |
priorityDate |
2003-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |