| abstract |
The present invention provides a fused pyrimidine derivative having an insulin secretion stimulating activity represented by Formula (I):n n{wherein R 1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X 1 and X 2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II):n nrepresents formula (III):n n[wherein X--Y--Z represents R 2 C=CR 3 -NR 4 (wherein R 2 , R 3 and R 4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof. |