http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1636231-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a44328611569062f569a4e08e3e6f23d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 2004-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602025b9136a7d7efec56a8bfc4a2281 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e15de500fffcfbe924cbe517f7f80fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_685777596a72f975d88d476b374be51a |
| publicationDate | 2010-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1636231-B1 |
| titleOfInvention | Methods for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine using a compound of 2-amino-9-(2-substituted ethyl)purines |
| abstract | The present invention relates to a new compound of 2-amino-9-(2-substituted ethyl)purine and an effective method for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurin (famciclovir) using the same. The 2-amino-9-(2-substituted ethyl)purine according to the invention is represented by the following formula (II'): (Formula II') wherein R is a hydroxy, halogen, mesyloxy or tosyloxy group. The inventive method for the preparation of famciclovir comprises the steps of halogenating 2-amino-9-(2-substituted ethyl)purine to give 2-amino-9-(2-halogenoethyl)purine, and reacting the halogenated compound with diethylmalonate. The inventive preparation method allows famciclovir, a purine derivative drug with effective antiviral activity, to be prepared in a high selectivity of 100% in a pure form by using the inventive new compound of 2-amino-9-(2-substituted ethyl)purine. In addition, the inventive method allows the utilization of relatively mild reaction conditions, and thus, has high industrial process efficiency. |
| priorityDate | 2003-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 210.