http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1636185-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_255d5714c2b71701ef3dbb905e5c7948 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 2004-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20b62db65fcd631b7e6a60bd8739722c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cab2f16f0699a8f676670f24767658f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d075cc96c7e675eb96aa90d45590ed4c |
| publicationDate | 2006-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1636185-A1 |
| titleOfInvention | Novel crystalline forms of perindopril erbumine |
| abstract | Disclosed are two novel crystalline forms d and e of perindopril erbumine, which are suitable as therapeutic substances in medicaments used for treating cardiovascular diseases, especially high blood pressure and cardiac insufficiency. Crystalline form e is obtained by crystallizing perindopril erbumine from MTBE containing 1.5 to 2.5 percent (v/v) of water at 30 to 45 DEG C, preferably 34 to 45 DEG C, crystallization expediently taking place by stirring. Crystalline form e changes into crystalline form d if the water is removed, practically by azeotropic distillation, preferably at 35 to 37 DEG C, and stirring continues for at least 15 h at 30 to 45 DEG C, preferably 35 to 37 DEG C. Crystalline form d can also be obtained by stirring crystalline form a or ss in tert-butyl methyl ether containing 0.9 to 1.4 percent (v/v) of water at 33 to 38 DEG C while inoculating the same with crystalline form d. Crystalline form e can further be obtained by stirring crystalline form a or ss in tert-butyl methyl ether containing 0.9 to 1.4 percent (v/v) of water at 28 to 35 DEG C while inoculating the same with crystalline form e, or by stirring crystalline form a or ss in tert-butyl methyl ether containing 1.5 to 2.0 percent (v/v) of water at 35 to 38 DEG C. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012044189-A1 |
| priorityDate | 2003-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.