http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1629116-A1

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filingDate 2004-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1e292f5bd22ce3e5243c7f8402d2932
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publicationDate 2006-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1629116-A1
titleOfInvention Method for detecting dna point mutations (single nucleotide polymorphism (snp) analysis) and associated arrangement
abstract The single nucleotide polymorphism (SNP) analysis involves the utilization of a DNA hybridization as well as the use of a DNA chip. A liquid DNA sample to be analyzed is guided over a DNA chip in a defined time course. After successful hybridization, the temperature is modified in a defined manner under low stringency conditions so that scavenger/target DNA hybrids are melted, whereby the melting of the scavenger/target DNA hybrids is detected and evaluated according to the temperature. In addition to the DNA chip (1), at least one device (10) is provided for controlling or regulating temperature, and a device (20, 30) is provided for the lateral flowing against of the surface (1) of the DNA chip (1). Factors for matching hybrids and mismatching/single point mismatching hybrids can be detected and evaluated using appropriate measuring means.
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