| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dee3727dba91e4e7aa3b26ce9efbcc21 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-18 |
| filingDate |
2004-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1279c6a0359fa23ac6ed64e17818324 |
| publicationDate |
2007-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1628995-B1 |
| titleOfInvention |
A process for the preparation of perindopril using tetramethyluronium salts as coupling reagents |
| abstract |
The present invention relates to the process for the preparation of the ACE inhibitor perindopril starting from stereospecific amino acid N-/1-(S)-ethoxy-carbonyl-butyl/-(S)-alanine which is activated with tetramethyluronium salts in the presence of tertiary organic base, following the reaction with (2S,3aS,7aS)-octahydroindolo-2-carboxylic acid or an ester thereof, and after completing the reaction followed by elimination of protective group by hydrogenation, phase transfer hydrogenation or extraction. |
| priorityDate |
2003-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |