Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_93d7b584586ed080ddaaf0246ddf9c93 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
filingDate |
2004-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6717915f63f51d8c7419b283ed57ba2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2329f8047d1f8f2bf74bc0063869363d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10a8554256a3f75e8c569194f1b847f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2155374465738f1151717a9e8b9a6d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ae8efd8d15026b231944b9d7aeaa2d |
publicationDate |
2006-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1625404-A1 |
titleOfInvention |
Gain of function sorting for drug discovery and development |
abstract |
The present disclosure provides compositions and methods for high throughput Gain of Function (GOF) sorting to discover and develop novel and highly selective candidate drug molecules. High throughput GOF sorting includes: mutating a single residue in a receptor and/or ligand; measuring the affinity and functional activity of the resulting ligand target-ligand interaction; and carrying out multiple rounds of mutation and measurement to determine which residues provide key interaction points underlying the functional activity of a ligand target-ligand interaction. Further, the present disclosure provides methods and compositions for high throughput and high precision GOF sorting, such that large numbers of mutations can be generated and screened rapidly, and GOF compounds can be identified and isolated. |
priorityDate |
2003-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |