| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30308d01c430325c4edee668985f62a4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2474
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01035
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-47 |
| filingDate |
1998-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5eab1ad20a9a2593dadc8ebb21cda48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6c4c83d36e45888b27ca3e365dc2173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2a83404c5b89aaff3e76d6448cd05db |
| publicationDate |
2008-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1624057-B1 |
| titleOfInvention |
Pharmaceutical composition containing hyaluronidase and uses thereof |
| abstract |
Production of a preparation containing hyaluronidase (I) involves (1) comminuting mammalian (especially steer) testes to a slurry, (2) eluting proteins and enzymes from with acid, (3) fractionally precipitating the eluate with ammonium sulphate (AS) to form a (I)-containing precipitate fraction, (4) dialysing this fraction to remove AS, (5) purifying the dialysate by adsorption-desorption on hydrated alumina and (6) using the purified (I) to produce galenic formulations. The novel features are that AS precipitation is effected in two steps, firstly at 10-29 wt.% then at 15-65 wt.%; and that the purified fraction from (5) is subjected to ulltrafiltration at an exclusion limit of 5-30 kD before formulating in step (6). |
| priorityDate |
1997-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |