| abstract |
A novel class of compounds of the general formula (I) in which R1 and R2 form a saturated or partially saturated bicyclic or tricyclic ring system, their use in therapy, pharma-ceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of dis-eases in which such a modulation is beneficial, e.g. the metabolic syndrome. |