| abstract |
The invention discloses a class of sequence-specific oligonucleotides for use in silencing genes. Specifically, the invention includes targetable oligonucleotides composed of RNA, DNA, nucleic acid analogs, or some combination of the above which have a configuration such that their introduction to a solution, cell, tissue, or organism containing the target gene causes silencing of the gene to which they are targeted. The invention also includes methods of silencing a gene by exposing a solution, cell, tissue, or organism with a compound comprising an oligonucleotide of the invention. Additionally, the invention provides recombinant vectors comprising nucleic acid molecules that code for the targeted oligonucleotides of the invention. |