| abstract |
The invention provides compounds having two spiro heterocyclic units connectednthrough a linker of a certain length. Some of these compounds have been obtained fromn Aplysinia sp. The compounds exhibit VDCC blocker activity as well asnacetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they arenuseful in the treatment of use in the treatment of brain ischemia, stroke, cognitive disordersnas senile dementia, cerebrovascular dementia, mild recognition impairment, attentionndeficit disorder, and/or neurodegenerative dementing disease with aberrant proteinnaggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jacobndisease or Gerstmann-Straussler-Scheinher disease. |