| abstract |
In the present invention, the methods of producing a fluorinated cyclic benzamidinenderivative (A), or a salt thereof, comprise the step of reacting a specific novel compound withnammonia or imide. n The methods of this invention for producing a morpholine-substituted phenacylnderivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine,nreaction of the product with a halogenating reagent, and deketalization of the product. n The methods of this invention for a producing cyclic benzamidine derivative (C), or ansalt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B),nor a salt thereof, in the presence of an ether or a hydrocarbon. n The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), orna salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixednsolvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, andnafter dissolution, adding additional water to precipitate crystals of compound (C), or the saltnthereof. |