| abstract |
Provided are excellent β-secretase inhibitors, that is, compoundsnrepresented by the general formula (1) or prodrugs thereof:n nwherein A is amino or protected amino; B 1 and B 2 are each a single bond,nalkylene of 1 to 3 carbon atoms, or the like; D is a single bond, -NHCO, ornthe like; E is -COOH, tetrazole ring, or the like; n is an integer of 1 to 3; mnis an integer of 1 to 3; G is hydroxyl, a group represented by the generalnformula (2), or the like:n n in which Z is -NH, -Asp-Ala-NH-, -Asp-Ala-, -Asp-NH-, or the like; Lnis a 5-to 10-membered ring optionally containing a heteroatom and/ornunsaturated bond; X is -COOH, tetrazole ring, or the like; Y is hydrogen,n-COOH, or the like; and k is an integer of 1 to 4; nand R 1 , R 2 , and R 3 are each alkyl of 1 to 6 carbon atoms, or the like. |