http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1599445-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-38 |
| filingDate | 2004-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab864a262ebe881b8476fe1521116175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6302b7bf4bd9c5e1490cb590114d2943 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3b89a0df7bc3f25707a51f76f9223ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a862432f911c89e04264a71038d5849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627ef1925ee8dfed3b4bf94951eaf81a |
| publicationDate | 2005-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1599445-A1 |
| titleOfInvention | Compounds having activity at 5ht2c receptor and uses thereof |
| abstract | Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein R<SUB>1 </SUB>is hydrogen, fluoro, chloro, hydroxy, C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkyloxy, C<SUB>1-6</SUB>alkoxy or haloC<SUB>1-6</SUB>alkoxy; m is 0 when - is a double bond and m is 1 when - is a single bond; R<SUB>2 </SUB>is hydrogen, halogen, cyano, nitro, C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkyloxy, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, haloC<SUB>1-6</SUB>alkoxy, C<SUB>1-6</SUB>alkylthio, amino, mono- or di-C<SUB>1-6</SUB>alkylamino or an N-linked 4 to 7 membered heterocyclic group; X is -(CH<SUB>2</SUB>-CH<SUB>2</SUB>)-, -(CH-CH)-, -(CH<SUB>2</SUB>)<SUB>3</SUB>-, -C(CH<SUB>3</SUB>)<SUB>2</SUB>-, -(CH-CH-CH<SUB>2</SUB>)-, -(CH<SUB>2</SUB>-CH-CH)- or a group -(CHR<SUB>5</SUB>)- wherein R<SUB>5 </SUB>is hydrogen, halogen, hydroxy, cyano, nitro, C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkyloxy, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, haloC<SUB>1-6</SUB>alkoxy or C<SUB>1-6</SUB>alkylthio; R<SUB>3 </SUB>is halogen, cyano, C<SUB>1-6</SUB>alkyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkyloxy, C<SUB>1-6</SUB>alkoxy, C<SUB>1-6</SUB>alkylthio, hydroxy, amino, mono- or di-C<SUB>1-6</SUB>alkylamino, an N-linked 4 to 7 membered heterocyclic group, nitro, haloC<SUB>1-6</SUB>alkyl, haloC<SUB>1-6</SUB>alkoxy, aryl, arylC<SUB>1-6</SUB>alkyl, arylC<SUB>1-6</SUB>alkyloxy, arylC<SUB>1-6</SUB>alkylthio or COOR<SUB>6</SUB>, CONR<SUB>7</SUB>R<SUB>8 </SUB>or COR<SUB>9 </SUB>wherein R<SUB>6</SUB>, R<SUB>7</SUB>, R<SUB>8 </SUB>and R<SUB>9 </SUB>are independently hydrogen or C<SUB>1-6</SUB>alkyl; p is 0, 1 or 2 or 3; R<SUB>4 </SUB>is hydrogen, halogen, hydroxy, cyano, nitro, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkanoyl, C<SUB>3-7</SUB>cycloalkyl, C<SUB>3-7</SUB>cycloalkyloxy, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkoxy, haloC<SUB>1-6</SUB>alkoxy, C<SUB>1-6</SUB>alkylthio, amino, mono- or di-C<SUB>1-6</SUB>alkylamino or an N-linked 4 to 7 membered heterocyclic group; Y is oxygen, sulfur, -CH<SUB>2</SUB>- or NR<SUB>10 </SUB>wherein R<SUB>10 </SUB>is hydrogen or C<SUB>1-6</SUB>alkyl; D is a single bond, -CH<SUB>2</SUB>-, -(CH<SUB>2</SUB>)<SUB>2</SUB>- or -CH-CH-; and Z is -NR<SUB>11</SUB>R<SUB>12 </SUB>where R<SUB>11 </SUB>and R<SUB>12 </SUB>are independently hydrogen or C<SUB>1-6</SUB>alkyl, or an optionally substituted N-linked or C-linked 4 to 7 membered heterocyclic group. Method of preparation and uses of the compounds in therapy, for example depression and anxiety, are also disclosed. |
| priorityDate | 2003-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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