| abstract |
The invention relates to the powder inhalant of sumatriptan andnthe method of preparation thereof. The powder inhalant ofnsumatriptan of the invention comprises sumatriptan 5-90 wt%,ncolloidal adherent(s) 1-95%, water insoluble binder (s) 0-90 wt%,ndiluent(s) 0-94%, and surfactant(s) 0-2 wt%. The formulationnof the invention can be used for the treatment of migraine. Afternthe administration of drugs by nasal inhalation, the drugsnabsorbed through membrana mucosa nasi, and acted systematically.nThe formulation can be present in the form of a single dose ofnsolid powder, which has an increased stability. All the powdernabsorbs through the cavity of nose, which leads to less amountnof drugs remained in the delivery device, and which depositsnon the sites more easily. Moreover, the formulation of theninvention can be carried by the patients conveniently. |