| abstract |
The invention relates to D-homoestra-1, 3, 5 (10)-trien-3-yl 2-substituted sulfamates of general formula (1), wherein R<3> is C1-C5 alkyl or a C1-C5 alkyloxy group and to the use thereof for producing a drug for curing tumoral diseases which can be positively influenced by inhibiting tubulin polymerisation. The inventive compounds are characterised by a D-homosubstitution, in a particular by the effect thereof for inhibiting the tubulin polymerisation and in that they can be used, for example for curing prostate carcinomas. |