| abstract |
A compound represented by the formula (1) [wherein R1 represents a 5- or 6-membered ring; R3 represents hydrogen, lower alkyl, or lower alkoxy; Z1 represents a 5- or 6-membered aromatic ring; Z2 represents a group represented by Z2a-W2-Z2b- (Z2a and Z2b each represents oxygen, S(O)m (m is 0, 1, or 2), imino, or a bond and W2 represents an optionally substituted alkylene chain); n is an integer of 0 to 4; Y represents oxygen, S(O)p (p is 0, 1, or 2), CH2, or NR4 (R4 represents hydrogen, a hydrocarbon group, a heterocyclic group, or acyl); and R2 represents (1) amino in which the nitrogen atom may be in the form of a quaternary ammonium or oxide, (2) a nitrogenous heterocyclic group in which the ring-constituting atoms may include sulfur or oxygen and the nitrogen atom may be in the form of a quaternary ammonium or oxide, etc.] or a salt of the compound. The compound has excellent antagonistic activity against CCR5 and is useful as a preventive/therapeutic agent for HIV infection in human peripheral blood mononuclear cells, especially for AIDS. |