http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1593385-A1

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filingDate 2004-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2ab5d614fc7516fb9c668fb8a37c5c3
publicationDate 2005-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1593385-A1
titleOfInvention Use of histones for the early diagnosis and/or preventive therapy of virus-infected living cells and a biochip for implementation of the diagnosis
abstract The invention of a biologically active ingredient, especially for early diagnosisnand / or preventive therapy of virus-infected live cells, wherein itsnEffectively directed against the cell membranes of virus-infected cellsnwhich are modified in a characteristic manner after the virus attack, wherein thenActive ingredient includes at least one ingredient selected from anGroup of substances consisting of histones, covalently modified histones,nhistone-like polypeptides and biologically active sequences of histones andnhistone-like peptides.n n n The active ingredient is, for example, recombinant humannHistone H1 or at least one histone H1 subtype (H1.0, H1.1, H1.2, H1.3, H1.4,nH1.5, H1.t, H1.x) or its active section. The adequatenSize of biological activity for killing a virus-infected cell on hernmodified cell membrane by cooperativity with same orndifferent active ingredients be achievable with each othernform a biologically active complex with enhanced biological activity.n n n The invention also relates to a biochip for the diagnosis of virus-infected cells,nbeing a selected number of different biological agentsneach with a biological activity located on the biochip, for identificationnan individual profile of the disease, with the active ingredients selectednare from a group of substances consisting of histones, covalently modifiednHistones, histone-like polypeptides and biologically active sequences ofnHistones and histone-like peptides.
priorityDate 2004-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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